| Santa Cruz de la Palma to Sestu | 1,695.71 mi (2,728.98 km) |
| Santa Cruz de la Palma to Settimo Torinese | 1,797.94 mi (2,893.50 km) |
| Santa Cruz de la Palma to Seveso | 1,873.16 mi (3,014.57 km) |
| Santa Cruz de la Palma to Sezze | 1,940.70 mi (3,123.26 km) |
| Santa Cruz de la Palma to Siano | 2,009.07 mi (3,233.29 km) |
| Santa Cruz de la Palma to Siena | 1,900.14 mi (3,057.97 km) |
| Santa Cruz de la Palma to Signa | 1,902.06 mi (3,061.06 km) |
| Santa Cruz de la Palma to Silea | 2,009.08 mi (3,233.29 km) |
| Santa Cruz de la Palma to Silvi Paese | 2,014.02 mi (3,241.25 km) |
| Santa Cruz de la Palma to Sinalunga | 1,916.21 mi (3,083.85 km) |
| Santa Cruz de la Palma to Siniscola | 1,753.87 mi (2,822.58 km) |
| Santa Cruz de la Palma to Sinnai | 1,701.45 mi (2,738.23 km) |
| Santa Cruz de la Palma to Siracusa | 1,992.19 mi (3,206.12 km) |
| Santa Cruz de la Palma to Solaro | 1,869.95 mi (3,009.39 km) |
| Santa Cruz de la Palma to Soliera | 1,921.57 mi (3,092.46 km) |
