| Senigallia to Settimo Torinese | 286.28 mi (460.72 km) |
| Senigallia to Seveso | 240.75 mi (387.46 km) |
| Senigallia to Sezze | 153.10 mi (246.40 km) |
| Senigallia to Siano | 214.79 mi (345.68 km) |
| Senigallia to Siena | 98.40 mi (158.36 km) |
| Senigallia to Signa | 105.84 mi (170.33 km) |
| Senigallia to Silea | 141.58 mi (227.85 km) |
| Senigallia to Silvi Paese | 92.25 mi (148.46 km) |
| Senigallia to Sinalunga | 81.99 mi (131.94 km) |
| Senigallia to Siniscola | 282.06 mi (453.93 km) |
| Senigallia to Sinnai | 368.71 mi (593.38 km) |
| Senigallia to Siracusa | 471.74 mi (759.19 km) |
| Senigallia to Solaro | 241.92 mi (389.33 km) |
| Senigallia to Soliera | 133.83 mi (215.39 km) |
| Senigallia to Solofra | 215.74 mi (347.20 km) |
