| Seymour to Enterprise (Nevada) | 1,614.29 mi (2,597.95 km) |
| Seymour to Enumclaw (Washington) | 1,889.93 mi (3,041.54 km) |
| Seymour to Ephrata (Pennsylvania) | 523.89 mi (843.12 km) |
| Seymour to Erie (Colorado) | 1,021.80 mi (1,644.43 km) |
| Seymour to Erie (Pennsylvania) | 375.73 mi (604.68 km) |
| Seymour to Erlanger (Kentucky) | 70.21 mi (113.00 km) |
| Seymour to Escanaba (Michigan) | 473.80 mi (762.50 km) |
| Seymour to Escondido (California) | 1,778.46 mi (2,862.15 km) |
| Seymour to Española (New Mexico) | 1,122.50 mi (1,806.49 km) |
| Seymour to Essex (Maryland) | 506.68 mi (815.43 km) |
| Seymour to Essex Junction (Vermont) | 760.86 mi (1,224.49 km) |
| Seymour to Estelle (Louisiana) | 672.99 mi (1,083.07 km) |
| Seymour to Estero (Florida) | 896.95 mi (1,443.51 km) |
| Seymour to Euclid (Ohio) | 293.99 mi (473.14 km) |
| Seymour to Eufaula (Alabama) | 488.02 mi (785.39 km) |
