| Shoreham-by-Sea to Savignano sul Rubicone | 751.48 mi (1,209.38 km) |
| Shoreham-by-Sea to Savona | 607.32 mi (977.38 km) |
| Shoreham-by-Sea to Scafati | 993.18 mi (1,598.36 km) |
| Shoreham-by-Sea to Scalea | 1,086.01 mi (1,747.76 km) |
| Shoreham-by-Sea to Scandiano | 666.33 mi (1,072.36 km) |
| Shoreham-by-Sea to Scandicci | 724.99 mi (1,166.76 km) |
| Shoreham-by-Sea to Schio | 640.17 mi (1,030.25 km) |
| Shoreham-by-Sea to Sciacca | 1,130.28 mi (1,819.01 km) |
| Shoreham-by-Sea to Scicli | 1,219.35 mi (1,962.35 km) |
| Shoreham-by-Sea to Scordia | 1,194.36 mi (1,922.14 km) |
| Shoreham-by-Sea to Scorze | 674.92 mi (1,086.17 km) |
| Shoreham-by-Sea to Sedico | 652.58 mi (1,050.22 km) |
| Shoreham-by-Sea to Sedriano | 563.19 mi (906.37 km) |
| Shoreham-by-Sea to Segni | 893.41 mi (1,437.81 km) |
| Shoreham-by-Sea to Segrate | 574.35 mi (924.32 km) |
