| Shoreham-by-Sea to Sestu | 917.02 mi (1,475.80 km) |
| Shoreham-by-Sea to Settimo Torinese | 541.04 mi (870.72 km) |
| Shoreham-by-Sea to Seveso | 561.52 mi (903.68 km) |
| Shoreham-by-Sea to Sezze | 904.75 mi (1,456.05 km) |
| Shoreham-by-Sea to Siano | 996.39 mi (1,603.53 km) |
| Shoreham-by-Sea to Siena | 751.90 mi (1,210.07 km) |
| Shoreham-by-Sea to Signa | 720.47 mi (1,159.49 km) |
| Shoreham-by-Sea to Silea | 678.78 mi (1,092.39 km) |
| Shoreham-by-Sea to Silvi Paese | 887.60 mi (1,428.46 km) |
| Shoreham-by-Sea to Sinalunga | 770.74 mi (1,240.39 km) |
| Shoreham-by-Sea to Siniscola | 855.01 mi (1,376.00 km) |
| Shoreham-by-Sea to Sinnai | 919.50 mi (1,479.79 km) |
| Shoreham-by-Sea to Siracusa | 1,221.01 mi (1,965.03 km) |
| Shoreham-by-Sea to Solaro | 560.98 mi (902.81 km) |
| Shoreham-by-Sea to Soliera | 667.81 mi (1,074.73 km) |
