| Shoreham-by-Sea to Spello | 814.68 mi (1,311.11 km) |
| Shoreham-by-Sea to Spilamberto | 680.82 mi (1,095.68 km) |
| Shoreham-by-Sea to Spilimbergo | 683.38 mi (1,099.79 km) |
| Shoreham-by-Sea to Spinea | 680.20 mi (1,094.68 km) |
| Shoreham-by-Sea to Spoleto | 826.80 mi (1,330.61 km) |
| Shoreham-by-Sea to Spoltore | 893.09 mi (1,437.29 km) |
| Shoreham-by-Sea to Spresiano | 671.73 mi (1,081.04 km) |
| Shoreham-by-Sea to Squinzano | 1,134.78 mi (1,826.25 km) |
| Shoreham-by-Sea to Statte | 1,097.02 mi (1,765.48 km) |
| Shoreham-by-Sea to Stezzano | 579.56 mi (932.71 km) |
| Shoreham-by-Sea to Strada | 737.95 mi (1,187.62 km) |
| Shoreham-by-Sea to Stradella | 594.18 mi (956.23 km) |
| Shoreham-by-Sea to Striano | 991.28 mi (1,595.31 km) |
| Shoreham-by-Sea to Subiaco | 883.16 mi (1,421.31 km) |
| Shoreham-by-Sea to Sulmona | 905.80 mi (1,457.74 km) |
