| Signa to Santa Venerina | 471.26 mi (758.42 km) |
| Signa to Santeramo in Colle | 355.35 mi (571.88 km) |
| Signa to Santo Stefano di Magra | 64.48 mi (103.77 km) |
| Signa to Santo Stino di Livenza | 155.51 mi (250.27 km) |
| Signa to Sarezzo | 136.33 mi (219.41 km) |
| Signa to Sarno | 272.55 mi (438.62 km) |
| Signa to Saronno | 162.67 mi (261.79 km) |
| Signa to Sarzana | 61.13 mi (98.38 km) |
| Signa to Sassari | 247.93 mi (399.01 km) |
| Signa to Sasso Marconi | 43.26 mi (69.61 km) |
| Signa to Sassuolo | 55.33 mi (89.05 km) |
| Signa to Sava | 405.47 mi (652.54 km) |
| Signa to Saviano | 263.90 mi (424.70 km) |
| Signa to Savigliano | 181.80 mi (292.57 km) |
| Signa to Savignano sul Panaro | 48.48 mi (78.02 km) |
