| Signa to Santander | 744.81 mi (1,198.66 km) |
| Signa to Santany | 512.89 mi (825.41 km) |
| Signa to Santiago de Compostela | 986.96 mi (1,588.37 km) |
| Signa to Santiago del Teide | 1,876.68 mi (3,020.22 km) |
| Signa to Santiponce | 997.88 mi (1,605.92 km) |
| Signa to Santomera | 746.22 mi (1,200.92 km) |
| Signa to Santona | 727.69 mi (1,171.10 km) |
| Signa to Santurce-Antiguo | 707.41 mi (1,138.47 km) |
| Signa to Sarria | 931.96 mi (1,499.85 km) |
| Signa to Sauzal | 1,851.08 mi (2,979.02 km) |
| Signa to Sedavi | 664.50 mi (1,069.42 km) |
| Signa to Segorbe | 654.92 mi (1,053.99 km) |
| Signa to Segovia | 799.94 mi (1,287.37 km) |
| Signa to Senmanat | 479.07 mi (770.99 km) |
| Signa to Sesena | 800.55 mi (1,288.36 km) |
