| Signa to Enumclaw (Washington) | 5,531.62 mi (8,902.27 km) |
| Signa to Ephrata (Pennsylvania) | 4,269.73 mi (6,871.47 km) |
| Signa to Erie (Colorado) | 5,414.69 mi (8,714.11 km) |
| Signa to Erie (Pennsylvania) | 4,356.95 mi (7,011.83 km) |
| Signa to Erlanger (Kentucky) | 4,675.44 mi (7,524.39 km) |
| Signa to Escanaba (Michigan) | 4,485.71 mi (7,219.05 km) |
| Signa to Escondido (California) | 6,200.26 mi (9,978.35 km) |
| Signa to Española (New Mexico) | 5,662.07 mi (9,112.22 km) |
| Signa to Essex (Maryland) | 4,316.28 mi (6,946.38 km) |
| Signa to Essex Junction (Vermont) | 3,975.12 mi (6,397.34 km) |
| Signa to Estelle (Louisiana) | 5,329.38 mi (8,576.81 km) |
| Signa to Estero (Florida) | 5,114.28 mi (8,230.65 km) |
| Signa to Euclid (Ohio) | 4,438.42 mi (7,142.94 km) |
| Signa to Eufaula (Alabama) | 5,016.25 mi (8,072.87 km) |
| Signa to Eugene (Oregon) | 5,744.93 mi (9,245.57 km) |
