| Sikeston to Shoreham-by-Sea | 4,275.13 mi (6,880.15 km) |
| Sikeston to Shotley Bridge | 4,103.71 mi (6,604.29 km) |
| Sikeston to Shrewsbury | 4,126.03 mi (6,640.21 km) |
| Sikeston to Sidcup | 4,272.66 mi (6,876.18 km) |
| Sikeston to Sidmouth | 4,161.05 mi (6,696.57 km) |
| Sikeston to Sileby | 4,188.95 mi (6,741.46 km) |
| Sikeston to Sittingbourne | 4,300.09 mi (6,920.32 km) |
| Sikeston to Skegness | 4,232.64 mi (6,811.77 km) |
| Sikeston to Skelmersdale | 4,103.28 mi (6,603.59 km) |
| Sikeston to Skipton | 4,121.36 mi (6,632.68 km) |
| Sikeston to Sleaford | 4,208.11 mi (6,772.30 km) |
| Sikeston to Slough | 4,243.28 mi (6,828.90 km) |
| Sikeston to Small Heath | 4,167.42 mi (6,706.81 km) |
| Sikeston to Smethwick | 4,162.17 mi (6,698.37 km) |
| Sikeston to Snaresbrook | 4,264.57 mi (6,863.17 km) |
