| Sikeston to Altus (Oklahoma) | 565.86 mi (910.66 km) |
| Sikeston to Alum Rock (California) | 1,767.42 mi (2,844.39 km) |
| Sikeston to Alvin (Texas) | 614.01 mi (988.16 km) |
| Sikeston to Amarillo (Texas) | 693.39 mi (1,115.91 km) |
| Sikeston to Amelia (Ohio) | 327.56 mi (527.16 km) |
| Sikeston to American Canyon (California) | 1,783.04 mi (2,869.52 km) |
| Sikeston to American Fork (Utah) | 1,219.26 mi (1,962.21 km) |
| Sikeston to Americus (Georgia) | 451.30 mi (726.30 km) |
| Sikeston to Ames (Iowa) | 415.15 mi (668.11 km) |
| Sikeston to Amherst (Ohio) | 502.50 mi (808.70 km) |
| Sikeston to Ammon (Idaho) | 1,260.71 mi (2,028.92 km) |
| Sikeston to Amsterdam (New York) | 915.07 mi (1,472.66 km) |
| Sikeston to Anacortes (Washington) | 1,840.71 mi (2,962.33 km) |
| Sikeston to Anaheim (California) | 1,600.82 mi (2,576.27 km) |
| Sikeston to Anchorage (Alaska) | 3,027.93 mi (4,872.98 km) |
