| Sikeston to Anoka (Minnesota) | 608.13 mi (978.70 km) |
| Sikeston to Ansonia (Connecticut) | 935.82 mi (1,506.05 km) |
| Sikeston to Antelope (California) | 1,730.55 mi (2,785.06 km) |
| Sikeston to Anthem (Arizona) | 1,283.34 mi (2,065.34 km) |
| Sikeston to Antioch (California) | 1,759.91 mi (2,832.30 km) |
| Sikeston to Antioch (Illinois) | 394.45 mi (634.80 km) |
| Sikeston to Apache Junction (Arizona) | 1,260.24 mi (2,028.17 km) |
| Sikeston to Apex (North Carolina) | 601.58 mi (968.15 km) |
| Sikeston to Apollo Beach (Florida) | 756.70 mi (1,217.79 km) |
| Sikeston to Apopka (Florida) | 733.31 mi (1,180.14 km) |
| Sikeston to Apple Valley (California) | 1,552.77 mi (2,498.95 km) |
| Sikeston to Apple Valley (Minnesota) | 574.85 mi (925.13 km) |
| Sikeston to Appleton (Wisconsin) | 514.62 mi (828.20 km) |
| Sikeston to Arbutus (Maryland) | 719.47 mi (1,157.88 km) |
| Sikeston to Arcadia (California) | 1,605.36 mi (2,583.58 km) |
