| Sikeston to Channelview (Texas) | 584.55 mi (940.74 km) |
| Sikeston to Chantilly (Virginia) | 675.87 mi (1,087.70 km) |
| Sikeston to Chaparral (New Mexico) | 1,013.08 mi (1,630.40 km) |
| Sikeston to Chapel Hill (North Carolina) | 590.01 mi (949.52 km) |
| Sikeston to Charleston (Illinois) | 195.19 mi (314.13 km) |
| Sikeston to Charleston (South Carolina) | 613.15 mi (986.77 km) |
| Sikeston to Charleston (West Virginia) | 446.82 mi (719.09 km) |
| Sikeston to Charlotte (North Carolina) | 502.56 mi (808.79 km) |
| Sikeston to Charlottesville (Virginia) | 613.69 mi (987.64 km) |
| Sikeston to Chaska (Minnesota) | 586.70 mi (944.20 km) |
| Sikeston to Chatham (Illinois) | 192.71 mi (310.14 km) |
| Sikeston to Chattanooga (Tennessee) | 273.24 mi (439.73 km) |
| Sikeston to Cheat Lake (West Virginia) | 561.36 mi (903.43 km) |
| Sikeston to Chelsea (Alabama) | 297.32 mi (478.49 km) |
| Sikeston to Chelsea (Massachusetts) | 1,055.39 mi (1,698.48 km) |
