| Sikeston to Clarksdale (Mississippi) | 194.02 mi (312.24 km) |
| Sikeston to Clarkston (Georgia) | 368.57 mi (593.15 km) |
| Sikeston to Clarksville (Indiana) | 231.46 mi (372.50 km) |
| Sikeston to Clarksville (Tennessee) | 126.30 mi (203.26 km) |
| Sikeston to Clawson (Michigan) | 518.84 mi (834.99 km) |
| Sikeston to Clay (Alabama) | 277.11 mi (445.96 km) |
| Sikeston to Clayton (California) | 1,767.50 mi (2,844.51 km) |
| Sikeston to Clayton (Missouri) | 128.12 mi (206.19 km) |
| Sikeston to Clayton (North Carolina) | 625.82 mi (1,007.15 km) |
| Sikeston to Clayton (Ohio) | 351.49 mi (565.67 km) |
| Sikeston to Clearfield (Utah) | 1,235.78 mi (1,988.80 km) |
| Sikeston to Clearlake (California) | 1,796.93 mi (2,891.88 km) |
| Sikeston to Clearwater (Florida) | 732.36 mi (1,178.62 km) |
| Sikeston to Cleburne (Texas) | 543.72 mi (875.03 km) |
| Sikeston to Clemmons (North Carolina) | 514.52 mi (828.05 km) |
