| Sikeston to Cloverleaf (Texas) | 586.56 mi (943.98 km) |
| Sikeston to Cloverly (Maryland) | 701.76 mi (1,129.37 km) |
| Sikeston to Clovis (California) | 1,656.81 mi (2,666.37 km) |
| Sikeston to Clovis (New Mexico) | 781.48 mi (1,257.67 km) |
| Sikeston to Clute (Texas) | 638.70 mi (1,027.88 km) |
| Sikeston to Coachella (California) | 1,508.88 mi (2,428.31 km) |
| Sikeston to Coalinga (California) | 1,700.21 mi (2,736.22 km) |
| Sikeston to Coamo (Puerto Rico) | 1,917.34 mi (3,085.66 km) |
| Sikeston to Coatesville (Pennsylvania) | 774.37 mi (1,246.23 km) |
| Sikeston to Cockeysville (Maryland) | 725.52 mi (1,167.62 km) |
| Sikeston to Cocoa (Florida) | 779.32 mi (1,254.20 km) |
| Sikeston to Cocoa Beach (Florida) | 787.33 mi (1,267.08 km) |
| Sikeston to Coconut Creek (Florida) | 917.17 mi (1,476.04 km) |
| Sikeston to Coeur d'Alene (Idaho) | 1,566.98 mi (2,521.81 km) |
| Sikeston to Cohoes (New York) | 933.63 mi (1,502.54 km) |
