| Sikeston to Crawfordsville (Indiana) | 262.21 mi (421.99 km) |
| Sikeston to Crest Hill (Illinois) | 333.30 mi (536.40 km) |
| Sikeston to Crestview (Florida) | 457.83 mi (736.81 km) |
| Sikeston to Crestwood (Illinois) | 343.39 mi (552.64 km) |
| Sikeston to Crestwood (Missouri) | 123.31 mi (198.44 km) |
| Sikeston to Creve Coeur (Missouri) | 131.34 mi (211.37 km) |
| Sikeston to Crofton (Maryland) | 717.81 mi (1,155.21 km) |
| Sikeston to Crossville (Tennessee) | 261.47 mi (420.79 km) |
| Sikeston to Crowley (Louisiana) | 487.80 mi (785.03 km) |
| Sikeston to Crowley (Texas) | 531.93 mi (856.06 km) |
| Sikeston to Crown Point (Indiana) | 335.15 mi (539.37 km) |
| Sikeston to Crystal (Minnesota) | 596.48 mi (959.94 km) |
| Sikeston to Crystal Lake (Illinois) | 375.47 mi (604.26 km) |
| Sikeston to Cudahy (California) | 1,616.51 mi (2,601.53 km) |
| Sikeston to Cudahy (Wisconsin) | 428.61 mi (689.78 km) |
