| Sikeston to Delaware (Ohio) | 422.82 mi (680.46 km) |
| Sikeston to Delhi (California) | 1,709.92 mi (2,751.85 km) |
| Sikeston to Delray Beach (Florida) | 910.61 mi (1,465.49 km) |
| Sikeston to Deltona (Florida) | 734.21 mi (1,181.60 km) |
| Sikeston to Deming (New Mexico) | 1,079.64 mi (1,737.52 km) |
| Sikeston to Denison (Texas) | 449.06 mi (722.70 km) |
| Sikeston to Dent (Ohio) | 311.85 mi (501.87 km) |
| Sikeston to Denton (Texas) | 496.54 mi (799.10 km) |
| Sikeston to Dentsville (South Carolina) | 522.83 mi (841.42 km) |
| Sikeston to Denver (Colorado) | 851.03 mi (1,369.60 km) |
| Sikeston to Depew (New York) | 710.51 mi (1,143.45 km) |
| Sikeston to Derby (Connecticut) | 934.80 mi (1,504.41 km) |
| Sikeston to Derby (Kansas) | 424.28 mi (682.81 km) |
| Sikeston to Des Moines (Iowa) | 388.78 mi (625.68 km) |
| Sikeston to Des Moines (Washington) | 1,810.10 mi (2,913.07 km) |
