| Sikeston to Des Plaines (Illinois) | 366.95 mi (590.55 km) |
| Sikeston to Desert Hot Springs (California) | 1,526.04 mi (2,455.92 km) |
| Sikeston to DeSoto (Texas) | 508.00 mi (817.55 km) |
| Sikeston to Destin (Florida) | 482.89 mi (777.13 km) |
| Sikeston to Destrehan (Louisiana) | 480.42 mi (773.17 km) |
| Sikeston to Detroit (Michigan) | 512.89 mi (825.42 km) |
| Sikeston to Diamond Bar (California) | 1,595.58 mi (2,567.84 km) |
| Sikeston to Diamond Springs (California) | 1,702.71 mi (2,740.25 km) |
| Sikeston to Dickinson (North Dakota) | 966.64 mi (1,555.66 km) |
| Sikeston to Dickinson (Texas) | 602.80 mi (970.11 km) |
| Sikeston to Dickson (Tennessee) | 135.84 mi (218.61 km) |
| Sikeston to Difficult Run (Virginia) | 681.24 mi (1,096.35 km) |
| Sikeston to Dinuba (California) | 1,644.52 mi (2,646.59 km) |
| Sikeston to Discovery Bay (California) | 1,749.93 mi (2,816.24 km) |
| Sikeston to Dix Hills (New York) | 913.83 mi (1,470.67 km) |
