| Sikeston to Duluth (Minnesota) | 695.75 mi (1,119.71 km) |
| Sikeston to Dumas (Texas) | 691.66 mi (1,113.12 km) |
| Sikeston to Dumont (New Jersey) | 882.62 mi (1,420.44 km) |
| Sikeston to Duncan (Oklahoma) | 494.59 mi (795.96 km) |
| Sikeston to Duncanville (Texas) | 508.32 mi (818.06 km) |
| Sikeston to Dundalk (Maryland) | 730.23 mi (1,175.20 km) |
| Sikeston to Dunedin (Florida) | 728.42 mi (1,172.28 km) |
| Sikeston to Dunkirk (New York) | 667.64 mi (1,074.46 km) |
| Sikeston to Dunmore (Pennsylvania) | 810.62 mi (1,304.57 km) |
| Sikeston to Dunwoody (Georgia) | 359.92 mi (579.24 km) |
| Sikeston to Durango (Colorado) | 1,007.04 mi (1,620.67 km) |
| Sikeston to Durant (Oklahoma) | 431.82 mi (694.95 km) |
| Sikeston to Durham (North Carolina) | 596.98 mi (960.74 km) |
| Sikeston to Dyer (Indiana) | 337.53 mi (543.20 km) |
| Sikeston to Dyersburg (Tennessee) | 59.13 mi (95.15 km) |
