| Sikeston to Eagan (Minnesota) | 578.85 mi (931.57 km) |
| Sikeston to Eagle (Idaho) | 1,481.32 mi (2,383.96 km) |
| Sikeston to Eagle Mountain (Utah) | 1,230.30 mi (1,979.97 km) |
| Sikeston to Eagle Pass (Texas) | 847.04 mi (1,363.18 km) |
| Sikeston to Easley (South Carolina) | 417.34 mi (671.65 km) |
| Sikeston to East Bakersfield (California) | 1,636.66 mi (2,633.95 km) |
| Sikeston to East Bethel (Minnesota) | 614.59 mi (989.08 km) |
| Sikeston to East Chicago (Indiana) | 348.18 mi (560.35 km) |
| Sikeston to East Cleveland (Ohio) | 535.22 mi (861.35 km) |
| Sikeston to East Glenville (New York) | 925.57 mi (1,489.56 km) |
| Sikeston to East Grand Rapids (Michigan) | 468.72 mi (754.33 km) |
| Sikeston to East Hemet (California) | 1,552.23 mi (2,498.07 km) |
| Sikeston to East Highland Park (Virginia) | 672.44 mi (1,082.18 km) |
| Sikeston to East Honolulu (Hawaii) | 4,165.87 mi (6,704.33 km) |
| Sikeston to East Islip (New York) | 920.46 mi (1,481.34 km) |
