| Sikeston to Eatontown (New Jersey) | 869.90 mi (1,399.96 km) |
| Sikeston to Eau Claire (Wisconsin) | 557.15 mi (896.64 km) |
| Sikeston to Echelon (New Jersey) | 815.52 mi (1,312.45 km) |
| Sikeston to Eden (North Carolina) | 545.91 mi (878.56 km) |
| Sikeston to Eden Prairie (Minnesota) | 586.04 mi (943.14 km) |
| Sikeston to Edgewater (Florida) | 741.87 mi (1,193.92 km) |
| Sikeston to Edgewater (New Jersey) | 881.63 mi (1,418.85 km) |
| Sikeston to Edgewood (Maryland) | 742.31 mi (1,194.63 km) |
| Sikeston to Edgewood (Washington) | 1,806.41 mi (2,907.13 km) |
| Sikeston to Edina (Minnesota) | 587.03 mi (944.73 km) |
| Sikeston to Edinburg (Texas) | 886.41 mi (1,426.54 km) |
| Sikeston to Edmond (Oklahoma) | 443.93 mi (714.44 km) |
| Sikeston to Edmonds (Washington) | 1,817.86 mi (2,925.56 km) |
| Sikeston to Edwards (Colorado) | 941.65 mi (1,515.44 km) |
| Sikeston to Edwardsville (Illinois) | 133.54 mi (214.91 km) |
