| Sikeston to Effingham (Illinois) | 164.42 mi (264.61 km) |
| Sikeston to Eggertsville (New York) | 708.18 mi (1,139.70 km) |
| Sikeston to Egypt Lake-Leto (Florida) | 738.28 mi (1,188.14 km) |
| Sikeston to El Cajon (California) | 1,572.02 mi (2,529.93 km) |
| Sikeston to El Campo (Texas) | 656.74 mi (1,056.92 km) |
| Sikeston to El Centro (California) | 1,495.02 mi (2,406.00 km) |
| Sikeston to El Cerrito (California) | 1,787.80 mi (2,877.19 km) |
| Sikeston to El Dorado (Arkansas) | 307.31 mi (494.58 km) |
| Sikeston to El Dorado (Kansas) | 404.57 mi (651.10 km) |
| Sikeston to El Dorado Hills (California) | 1,714.10 mi (2,758.57 km) |
| Sikeston to El Mirage (Arizona) | 1,300.06 mi (2,092.25 km) |
| Sikeston to El Monte (California) | 1,606.00 mi (2,584.60 km) |
| Sikeston to El Paso (Texas) | 1,019.94 mi (1,641.43 km) |
| Sikeston to El Paso de Robles (California) | 1,725.36 mi (2,776.69 km) |
| Sikeston to El Reno (Oklahoma) | 476.00 mi (766.05 km) |
