| Sikeston to Elyria (Ohio) | 506.68 mi (815.42 km) |
| Sikeston to Emeryville (California) | 1,788.08 mi (2,877.64 km) |
| Sikeston to Emmaus (Pennsylvania) | 799.35 mi (1,286.42 km) |
| Sikeston to Emporia (Kansas) | 376.18 mi (605.41 km) |
| Sikeston to Encinitas (California) | 1,583.42 mi (2,548.26 km) |
| Sikeston to Endicott (New York) | 804.75 mi (1,295.12 km) |
| Sikeston to Endwell (New York) | 807.27 mi (1,299.18 km) |
| Sikeston to Englewood (Colorado) | 856.10 mi (1,377.76 km) |
| Sikeston to Englewood (Florida) | 805.08 mi (1,295.65 km) |
| Sikeston to Englewood (New Jersey) | 882.72 mi (1,420.60 km) |
| Sikeston to Englewood (Ohio) | 352.29 mi (566.95 km) |
| Sikeston to Enid (Oklahoma) | 460.19 mi (740.60 km) |
| Sikeston to Ennis (Texas) | 509.51 mi (819.98 km) |
| Sikeston to Ensley (Florida) | 459.05 mi (738.77 km) |
| Sikeston to Enterprise (Alabama) | 439.53 mi (707.36 km) |
