| Sikeston to Enterprise (Nevada) | 1,422.05 mi (2,288.58 km) |
| Sikeston to Enumclaw (Washington) | 1,792.51 mi (2,884.76 km) |
| Sikeston to Ephrata (Pennsylvania) | 758.64 mi (1,220.92 km) |
| Sikeston to Erie (Colorado) | 862.68 mi (1,388.35 km) |
| Sikeston to Erie (Pennsylvania) | 622.22 mi (1,001.37 km) |
| Sikeston to Erlanger (Kentucky) | 309.48 mi (498.06 km) |
| Sikeston to Escanaba (Michigan) | 625.80 mi (1,007.13 km) |
| Sikeston to Escondido (California) | 1,571.23 mi (2,528.64 km) |
| Sikeston to Española (New Mexico) | 916.90 mi (1,475.60 km) |
| Sikeston to Essex (Maryland) | 733.18 mi (1,179.94 km) |
| Sikeston to Essex Junction (Vermont) | 1,007.61 mi (1,621.59 km) |
| Sikeston to Estelle (Louisiana) | 487.37 mi (784.34 km) |
| Sikeston to Estero (Florida) | 854.87 mi (1,375.78 km) |
| Sikeston to Euclid (Ohio) | 540.09 mi (869.18 km) |
| Sikeston to Eufaula (Alabama) | 426.68 mi (686.67 km) |
