| Sikeston to Eugene (Oregon) | 1,816.77 mi (2,923.80 km) |
| Sikeston to Euless (Texas) | 507.78 mi (817.19 km) |
| Sikeston to Eureka (California) | 1,867.61 mi (3,005.64 km) |
| Sikeston to Eureka (Missouri) | 125.77 mi (202.41 km) |
| Sikeston to Eustis (Florida) | 719.46 mi (1,157.85 km) |
| Sikeston to Evans (Colorado) | 851.22 mi (1,369.91 km) |
| Sikeston to Evans (Georgia) | 479.03 mi (770.92 km) |
| Sikeston to Evanston (Illinois) | 370.59 mi (596.40 km) |
| Sikeston to Evanston (Wyoming) | 1,182.46 mi (1,902.98 km) |
| Sikeston to Evansville (Indiana) | 136.00 mi (218.87 km) |
| Sikeston to Everett (Massachusetts) | 1,054.49 mi (1,697.04 km) |
| Sikeston to Everett (Washington) | 1,811.56 mi (2,915.43 km) |
| Sikeston to Evergreen Park (Illinois) | 348.99 mi (561.65 km) |
| Sikeston to Ewa Beach (Hawaii) | 4,180.88 mi (6,728.47 km) |
| Sikeston to Ewa Gentry (Hawaii) | 4,181.33 mi (6,729.21 km) |
