| Sikeston to Hutchinson (Kansas) | 463.31 mi (745.63 km) |
| Sikeston to Hutchinson (Minnesota) | 606.44 mi (975.97 km) |
| Sikeston to Hutto (Texas) | 633.04 mi (1,018.78 km) |
| Sikeston to Hyattsville (Maryland) | 702.69 mi (1,130.87 km) |
| Sikeston to Hybla Valley (Virginia) | 694.03 mi (1,116.93 km) |
| Sikeston to Idaho Falls (Idaho) | 1,264.78 mi (2,035.47 km) |
| Sikeston to Idylwood (Virginia) | 688.66 mi (1,108.30 km) |
| Sikeston to Ilchester (Maryland) | 715.19 mi (1,150.99 km) |
| Sikeston to Immokalee (Florida) | 866.79 mi (1,394.96 km) |
| Sikeston to Imperial (California) | 1,494.58 mi (2,405.29 km) |
| Sikeston to Imperial Beach (California) | 1,585.76 mi (2,552.04 km) |
| Sikeston to Independence (Kentucky) | 309.44 mi (497.99 km) |
| Sikeston to Independence (Missouri) | 300.60 mi (483.77 km) |
| Sikeston to Indian Trail (North Carolina) | 515.28 mi (829.26 km) |
| Sikeston to Indiana (Pennsylvania) | 618.03 mi (994.63 km) |
