| Sikeston to Indianapolis (Indiana) | 273.30 mi (439.84 km) |
| Sikeston to Indianola (Iowa) | 375.61 mi (604.49 km) |
| Sikeston to Indio (California) | 1,513.10 mi (2,435.11 km) |
| Sikeston to Inglewood (California) | 1,625.55 mi (2,616.07 km) |
| Sikeston to Inkster (Michigan) | 500.88 mi (806.09 km) |
| Sikeston to Inver Grove Heights (Minnesota) | 577.63 mi (929.60 km) |
| Sikeston to Inwood (New York) | 890.08 mi (1,432.45 km) |
| Sikeston to Iona (Florida) | 844.45 mi (1,359.01 km) |
| Sikeston to Ionia (Michigan) | 483.95 mi (778.84 km) |
| Sikeston to Iowa City (Iowa) | 345.57 mi (556.15 km) |
| Sikeston to Irmo (South Carolina) | 509.53 mi (820.00 km) |
| Sikeston to Irondale (Alabama) | 283.87 mi (456.85 km) |
| Sikeston to Ironton (Ohio) | 394.35 mi (634.65 km) |
| Sikeston to Irvine (California) | 1,599.26 mi (2,573.75 km) |
| Sikeston to Irving (Texas) | 502.29 mi (808.36 km) |
