| Sikeston to Isabela (Puerto Rico) | 1,866.62 mi (3,004.04 km) |
| Sikeston to Iselin (New Jersey) | 860.26 mi (1,384.45 km) |
| Sikeston to Isla Vista (California) | 1,701.16 mi (2,737.75 km) |
| Sikeston to Issaquah (Washington) | 1,800.00 mi (2,896.82 km) |
| Sikeston to Ithaca (New York) | 793.61 mi (1,277.19 km) |
| Sikeston to Ives Estates (Florida) | 935.31 mi (1,505.23 km) |
| Sikeston to Jackson (Michigan) | 461.61 mi (742.89 km) |
| Sikeston to Jackson (Mississippi) | 317.73 mi (511.33 km) |
| Sikeston to Jackson (Missouri) | 34.30 mi (55.20 km) |
| Sikeston to Jackson (Tennessee) | 94.85 mi (152.65 km) |
| Sikeston to Jackson (Wyoming) | 1,203.22 mi (1,936.40 km) |
| Sikeston to Jacksonville (Alabama) | 303.02 mi (487.66 km) |
| Sikeston to Jacksonville (Arkansas) | 198.60 mi (319.61 km) |
| Sikeston to Jacksonville (Florida) | 641.65 mi (1,032.63 km) |
| Sikeston to Jacksonville (Illinois) | 199.56 mi (321.17 km) |
