| Sikeston to LaGrange (Georgia) | 370.61 mi (596.43 km) |
| Sikeston to Laguna Beach (California) | 1,601.10 mi (2,576.72 km) |
| Sikeston to Laguna Hills (California) | 1,596.77 mi (2,569.75 km) |
| Sikeston to Laguna Niguel (California) | 1,598.34 mi (2,572.28 km) |
| Sikeston to Laguna Woods (California) | 1,598.12 mi (2,571.92 km) |
| Sikeston to Lahaina (Hawaii) | 4,122.38 mi (6,634.34 km) |
| Sikeston to Lake Arbor (Maryland) | 708.85 mi (1,140.79 km) |
| Sikeston to Lake Barcroft (Virginia) | 690.86 mi (1,111.83 km) |
| Sikeston to Lake Butler (Florida) | 744.64 mi (1,198.38 km) |
| Sikeston to Lake Charles (Louisiana) | 506.68 mi (815.42 km) |
| Sikeston to Lake City (Florida) | 610.97 mi (983.27 km) |
| Sikeston to Lake Elmo (Minnesota) | 586.25 mi (943.48 km) |
| Sikeston to Lake Elsinore (California) | 1,574.83 mi (2,534.44 km) |
| Sikeston to Lake Forest (California) | 1,593.92 mi (2,565.16 km) |
| Sikeston to Lake Forest (Illinois) | 381.09 mi (613.30 km) |
