| Sikeston to Laredo (Texas) | 864.81 mi (1,391.78 km) |
| Sikeston to Largo (Florida) | 736.24 mi (1,184.86 km) |
| Sikeston to Largo (Maryland) | 708.67 mi (1,140.49 km) |
| Sikeston to Larkspur (California) | 1,799.96 mi (2,896.75 km) |
| Sikeston to Las Cruces (New Mexico) | 1,025.97 mi (1,651.14 km) |
| Sikeston to Las Vegas (Nevada) | 1,421.49 mi (2,287.66 km) |
| Sikeston to Las Vegas (New Mexico) | 874.66 mi (1,407.62 km) |
| Sikeston to Latham (New York) | 930.90 mi (1,498.14 km) |
| Sikeston to Lathrop (California) | 1,735.37 mi (2,792.81 km) |
| Sikeston to Lauderdale Lakes (Florida) | 922.93 mi (1,485.32 km) |
| Sikeston to Lauderhill (Florida) | 922.59 mi (1,484.76 km) |
| Sikeston to Laurel (Florida) | 791.26 mi (1,273.41 km) |
| Sikeston to Laurel (Maryland) | 708.92 mi (1,140.89 km) |
| Sikeston to Laurel (Mississippi) | 359.47 mi (578.51 km) |
| Sikeston to Laurel (Virginia) | 665.93 mi (1,071.71 km) |
