| Sikeston to Laurinburg (North Carolina) | 584.81 mi (941.17 km) |
| Sikeston to Lawndale (California) | 1,627.29 mi (2,618.87 km) |
| Sikeston to Lawrence (Indiana) | 283.53 mi (456.29 km) |
| Sikeston to Lawrence (Kansas) | 340.89 mi (548.60 km) |
| Sikeston to Lawrence (Massachusetts) | 1,054.66 mi (1,697.30 km) |
| Sikeston to Lawrenceburg (Kentucky) | 268.85 mi (432.68 km) |
| Sikeston to Lawrenceburg (Tennessee) | 169.21 mi (272.32 km) |
| Sikeston to Lawrenceville (Georgia) | 374.46 mi (602.63 km) |
| Sikeston to Lawton (Oklahoma) | 519.23 mi (835.61 km) |
| Sikeston to Layton (Utah) | 1,232.39 mi (1,983.34 km) |
| Sikeston to Le Mars (Iowa) | 536.32 mi (863.12 km) |
| Sikeston to League City (Texas) | 602.37 mi (969.42 km) |
| Sikeston to Lealman (Florida) | 744.24 mi (1,197.73 km) |
| Sikeston to Leander (Texas) | 644.70 mi (1,037.54 km) |
| Sikeston to Leavenworth (Kansas) | 335.41 mi (539.79 km) |
