| Sikeston to Lewiston (Idaho) | 1,549.71 mi (2,494.02 km) |
| Sikeston to Lewiston (Maine) | 1,131.65 mi (1,821.22 km) |
| Sikeston to Lewisville (North Carolina) | 512.07 mi (824.10 km) |
| Sikeston to Lewisville (Texas) | 495.40 mi (797.27 km) |
| Sikeston to Lexington (Kentucky) | 292.38 mi (470.53 km) |
| Sikeston to Lexington (Nebraska) | 608.79 mi (979.76 km) |
| Sikeston to Lexington (North Carolina) | 523.82 mi (843.00 km) |
| Sikeston to Lexington (South Carolina) | 511.54 mi (823.25 km) |
| Sikeston to Lexington Park (Maryland) | 725.44 mi (1,167.48 km) |
| Sikeston to Liberal (Kansas) | 625.85 mi (1,007.21 km) |
| Sikeston to Liberty (Missouri) | 309.01 mi (497.31 km) |
| Sikeston to Liberty Lake (Washington) | 1,579.91 mi (2,542.61 km) |
| Sikeston to Liberty Triangle (Florida) | 687.62 mi (1,106.62 km) |
| Sikeston to Libertyville (Illinois) | 383.04 mi (616.44 km) |
| Sikeston to Lighthouse Point (Florida) | 920.63 mi (1,481.62 km) |
