| Sikeston to Lovington (New Mexico) | 824.63 mi (1,327.12 km) |
| Sikeston to Lowell (Indiana) | 325.86 mi (524.43 km) |
| Sikeston to Lowell (Massachusetts) | 1,045.71 mi (1,682.91 km) |
| Sikeston to Lower Burrell (Pennsylvania) | 589.79 mi (949.18 km) |
| Sikeston to Lowes Island (Virginia) | 682.43 mi (1,098.26 km) |
| Sikeston to Lubbock (Texas) | 730.50 mi (1,175.62 km) |
| Sikeston to Lufkin (Texas) | 483.81 mi (778.61 km) |
| Sikeston to Luling (Louisiana) | 484.59 mi (779.88 km) |
| Sikeston to Lumberton (North Carolina) | 612.35 mi (985.48 km) |
| Sikeston to Lumberton (Texas) | 529.45 mi (852.07 km) |
| Sikeston to Lutz (Florida) | 733.11 mi (1,179.83 km) |
| Sikeston to Lynbrook (New York) | 894.51 mi (1,439.58 km) |
| Sikeston to Lynchburg (Virginia) | 573.43 mi (922.85 km) |
| Sikeston to Lynden (Washington) | 1,840.70 mi (2,962.32 km) |
| Sikeston to Lyndhurst (Ohio) | 538.39 mi (866.46 km) |
