| Sikeston to Odenton (Maryland) | 717.57 mi (1,154.82 km) |
| Sikeston to Odessa (Texas) | 804.52 mi (1,294.74 km) |
| Sikeston to Ogden (Utah) | 1,233.89 mi (1,985.76 km) |
| Sikeston to Oildale (California) | 1,639.08 mi (2,637.85 km) |
| Sikeston to Ojus (Florida) | 936.48 mi (1,507.12 km) |
| Sikeston to Okemos (Michigan) | 486.77 mi (783.39 km) |
| Sikeston to Oklahoma City (Oklahoma) | 452.62 mi (728.42 km) |
| Sikeston to Okmulgee (Oklahoma) | 368.23 mi (592.61 km) |
| Sikeston to Olathe (Kansas) | 316.90 mi (509.99 km) |
| Sikeston to Old Jamestown (Missouri) | 140.26 mi (225.72 km) |
| Sikeston to Oldsmar (Florida) | 731.08 mi (1,176.55 km) |
| Sikeston to Olean (New York) | 693.99 mi (1,116.86 km) |
| Sikeston to Olive Branch (Mississippi) | 133.75 mi (215.25 km) |
| Sikeston to Olivehurst (California) | 1,738.61 mi (2,798.03 km) |
| Sikeston to Olney (Maryland) | 698.37 mi (1,123.92 km) |
