| Sikeston to Olympia (Washington) | 1,832.23 mi (2,948.69 km) |
| Sikeston to Olympia Heights (Florida) | 943.75 mi (1,518.82 km) |
| Sikeston to Omaha (Nebraska) | 459.90 mi (740.14 km) |
| Sikeston to On Top of the World Designated Place (Florida) | 683.55 mi (1,100.07 km) |
| Sikeston to Onalaska (Wisconsin) | 491.28 mi (790.63 km) |
| Sikeston to Oneida (New York) | 850.77 mi (1,369.18 km) |
| Sikeston to Oneonta (New York) | 861.26 mi (1,386.06 km) |
| Sikeston to Ontario (California) | 1,583.27 mi (2,548.02 km) |
| Sikeston to Ontario (Oregon) | 1,513.73 mi (2,436.12 km) |
| Sikeston to Opa-locka (Florida) | 936.46 mi (1,507.09 km) |
| Sikeston to Opelika (Alabama) | 377.13 mi (606.93 km) |
| Sikeston to Opelousas (Louisiana) | 462.18 mi (743.81 km) |
| Sikeston to Orange (California) | 1,599.51 mi (2,574.17 km) |
| Sikeston to Orange (Texas) | 525.33 mi (845.44 km) |
| Sikeston to Orange City (Florida) | 729.78 mi (1,174.46 km) |
