| Sikeston to Orangeburg (South Carolina) | 545.06 mi (877.20 km) |
| Sikeston to Orangevale (California) | 1,723.23 mi (2,773.27 km) |
| Sikeston to Orchards (Washington) | 1,800.14 mi (2,897.04 km) |
| Sikeston to Orcutt (California) | 1,724.38 mi (2,775.12 km) |
| Sikeston to Oregon (Ohio) | 465.48 mi (749.12 km) |
| Sikeston to Oregon (Wisconsin) | 417.45 mi (671.82 km) |
| Sikeston to Oregon City (Oregon) | 1,799.93 mi (2,896.71 km) |
| Sikeston to Orem (Utah) | 1,213.82 mi (1,953.46 km) |
| Sikeston to Orinda (California) | 1,781.50 mi (2,867.05 km) |
| Sikeston to Orland Park (Illinois) | 339.06 mi (545.66 km) |
| Sikeston to Orlando (Florida) | 752.78 mi (1,211.49 km) |
| Sikeston to Ormond Beach (Florida) | 717.75 mi (1,155.11 km) |
| Sikeston to Oro Valley (Arizona) | 1,251.25 mi (2,013.69 km) |
| Sikeston to Oroville (California) | 1,736.59 mi (2,794.78 km) |
| Sikeston to Oshkosh (Wisconsin) | 496.07 mi (798.34 km) |
