| Sikeston to Oskaloosa (Iowa) | 345.64 mi (556.26 km) |
| Sikeston to Oswego (Illinois) | 338.18 mi (544.24 km) |
| Sikeston to Oswego (New York) | 825.08 mi (1,327.85 km) |
| Sikeston to Otsego (Minnesota) | 615.74 mi (990.94 km) |
| Sikeston to Ottawa (Illinois) | 311.54 mi (501.37 km) |
| Sikeston to Ottawa (Kansas) | 331.89 mi (534.12 km) |
| Sikeston to Ottumwa (Iowa) | 323.57 mi (520.73 km) |
| Sikeston to Overland (Missouri) | 132.21 mi (212.77 km) |
| Sikeston to Overland Park (Kansas) | 310.49 mi (499.69 km) |
| Sikeston to Overlea (Maryland) | 730.04 mi (1,174.88 km) |
| Sikeston to Oviedo (Florida) | 748.52 mi (1,204.62 km) |
| Sikeston to Owasso (Oklahoma) | 348.76 mi (561.28 km) |
| Sikeston to Owatonna (Minnesota) | 533.27 mi (858.21 km) |
| Sikeston to Owensboro (Kentucky) | 148.51 mi (239.00 km) |
| Sikeston to Owings Mills (Maryland) | 716.18 mi (1,152.59 km) |
