| Sikeston to Owosso (Michigan) | 510.04 mi (820.84 km) |
| Sikeston to Oxford (Alabama) | 309.26 mi (497.70 km) |
| Sikeston to Oxford (Mississippi) | 174.33 mi (280.55 km) |
| Sikeston to Oxford (Ohio) | 319.21 mi (513.72 km) |
| Sikeston to Oxnard (California) | 1,667.44 mi (2,683.49 km) |
| Sikeston to Oxon Hill (Maryland) | 700.21 mi (1,126.87 km) |
| Sikeston to Ozark (Alabama) | 437.77 mi (704.52 km) |
| Sikeston to Ozark (Missouri) | 200.56 mi (322.77 km) |
| Sikeston to Pace (Florida) | 454.72 mi (731.80 km) |
| Sikeston to Pacific Grove (California) | 1,781.65 mi (2,867.30 km) |
| Sikeston to Pacifica (California) | 1,800.35 mi (2,897.39 km) |
| Sikeston to Paducah (Kentucky) | 53.65 mi (86.33 km) |
| Sikeston to Pahrump (Nevada) | 1,461.82 mi (2,352.58 km) |
| Sikeston to Painesville (Ohio) | 556.60 mi (895.76 km) |
| Sikeston to Palatine (Illinois) | 370.78 mi (596.71 km) |
