| Sikeston to Reedley (California) | 1,646.53 mi (2,649.84 km) |
| Sikeston to Reidsville (North Carolina) | 550.96 mi (886.68 km) |
| Sikeston to Reisterstown (Maryland) | 715.52 mi (1,151.52 km) |
| Sikeston to Rendon (Texas) | 526.10 mi (846.68 km) |
| Sikeston to Reno (Nevada) | 1,645.16 mi (2,647.63 km) |
| Sikeston to Renton (Washington) | 1,805.66 mi (2,905.93 km) |
| Sikeston to Republic (Missouri) | 213.52 mi (343.63 km) |
| Sikeston to Reston (Virginia) | 681.76 mi (1,097.19 km) |
| Sikeston to Revere (Massachusetts) | 1,057.20 mi (1,701.40 km) |
| Sikeston to Rexburg (Idaho) | 1,258.60 mi (2,025.52 km) |
| Sikeston to Reynoldsburg (Ohio) | 424.46 mi (683.11 km) |
| Sikeston to Rialto (California) | 1,569.86 mi (2,526.45 km) |
| Sikeston to Richardson (Texas) | 485.44 mi (781.23 km) |
| Sikeston to Richfield (Minnesota) | 584.72 mi (941.01 km) |
| Sikeston to Richfield (Wisconsin) | 444.59 mi (715.49 km) |
