| Sikeston to Sacramento (California) | 1,737.39 mi (2,796.06 km) |
| Sikeston to Saddlebrooke (Arizona) | 1,242.39 mi (1,999.43 km) |
| Sikeston to Safety Harbor (Florida) | 732.74 mi (1,179.23 km) |
| Sikeston to Saginaw (Michigan) | 540.51 mi (869.87 km) |
| Sikeston to Saginaw (Texas) | 520.78 mi (838.11 km) |
| Sikeston to Sahuarita (Arizona) | 1,262.68 mi (2,032.08 km) |
| Sikeston to Saks (Alabama) | 303.95 mi (489.16 km) |
| Sikeston to Salem (Massachusetts) | 1,063.91 mi (1,712.19 km) |
| Sikeston to Salem (Ohio) | 545.45 mi (877.81 km) |
| Sikeston to Salem (Oregon) | 1,817.52 mi (2,925.01 km) |
| Sikeston to Salem (Virginia) | 525.90 mi (846.36 km) |
| Sikeston to Salem Lakes (Wisconsin) | 398.05 mi (640.60 km) |
| Sikeston to Salida (California) | 1,723.93 mi (2,774.40 km) |
| Sikeston to Salina (Kansas) | 457.55 mi (736.35 km) |
| Sikeston to Salinas (California) | 1,764.75 mi (2,840.09 km) |
