| Sikeston to Sanford (Florida) | 738.09 mi (1,187.84 km) |
| Sikeston to Sanford (Maine) | 1,088.98 mi (1,752.54 km) |
| Sikeston to Sanford (North Carolina) | 588.22 mi (946.65 km) |
| Sikeston to Sanger (California) | 1,651.41 mi (2,657.69 km) |
| Sikeston to Santa Ana (California) | 1,604.10 mi (2,581.55 km) |
| Sikeston to Santa Barbara (California) | 1,693.09 mi (2,724.77 km) |
| Sikeston to Santa Clara (California) | 1,775.30 mi (2,857.06 km) |
| Sikeston to Santa Clara (Oregon) | 1,817.91 mi (2,925.64 km) |
| Sikeston to Santa Clarita (California) | 1,625.74 mi (2,616.38 km) |
| Sikeston to Santa Cruz (California) | 1,783.23 mi (2,869.83 km) |
| Sikeston to Santa Fe (New Mexico) | 915.97 mi (1,474.12 km) |
| Sikeston to Santa Fe (Texas) | 607.99 mi (978.46 km) |
| Sikeston to Santa Fe Springs (California) | 1,610.41 mi (2,591.71 km) |
| Sikeston to Santa Maria (California) | 1,724.48 mi (2,775.29 km) |
| Sikeston to Santa Monica (California) | 1,631.87 mi (2,626.25 km) |
