| Sikeston to Santa Paula (California) | 1,658.26 mi (2,668.70 km) |
| Sikeston to Santa Rosa (California) | 1,804.86 mi (2,904.65 km) |
| Sikeston to Santaquin (Utah) | 1,217.42 mi (1,959.25 km) |
| Sikeston to Santee (California) | 1,572.24 mi (2,530.28 km) |
| Sikeston to Sapulpa (Oklahoma) | 366.92 mi (590.49 km) |
| Sikeston to Saraland (Alabama) | 425.77 mi (685.21 km) |
| Sikeston to Sarasota (Florida) | 777.26 mi (1,250.88 km) |
| Sikeston to Sarasota Springs (Florida) | 781.17 mi (1,257.17 km) |
| Sikeston to Saratoga (California) | 1,779.50 mi (2,863.83 km) |
| Sikeston to Saratoga Springs (New York) | 937.67 mi (1,509.03 km) |
| Sikeston to Saratoga Springs (Utah) | 1,225.40 mi (1,972.09 km) |
| Sikeston to Sartell (Minnesota) | 649.34 mi (1,045.02 km) |
| Sikeston to Satellite Beach (Florida) | 796.61 mi (1,282.02 km) |
| Sikeston to Sauk Rapids (Minnesota) | 646.76 mi (1,040.86 km) |
| Sikeston to Sault Ste. Marie (Michigan) | 715.16 mi (1,150.94 km) |
