| Sikeston to Scottsbluff (Nebraska) | 825.42 mi (1,328.38 km) |
| Sikeston to Scottsboro (Alabama) | 251.65 mi (404.99 km) |
| Sikeston to Scottsdale (Arizona) | 1,272.68 mi (2,048.18 km) |
| Sikeston to Scranton (Pennsylvania) | 807.55 mi (1,299.63 km) |
| Sikeston to Seabrook (Maryland) | 708.44 mi (1,140.12 km) |
| Sikeston to Seabrook (Texas) | 594.55 mi (956.83 km) |
| Sikeston to Seaford (New York) | 903.99 mi (1,454.84 km) |
| Sikeston to Seagoville (Texas) | 491.16 mi (790.44 km) |
| Sikeston to Seal Beach (California) | 1,614.24 mi (2,597.87 km) |
| Sikeston to Searcy (Arkansas) | 165.16 mi (265.80 km) |
| Sikeston to Seaside (California) | 1,775.83 mi (2,857.92 km) |
| Sikeston to SeaTac (Washington) | 1,810.06 mi (2,913.01 km) |
| Sikeston to Seattle (Washington) | 1,813.76 mi (2,918.96 km) |
| Sikeston to Sebastian (Florida) | 822.63 mi (1,323.89 km) |
| Sikeston to Sebring (Florida) | 804.76 mi (1,295.14 km) |
