| Sikeston to Secaucus (New Jersey) | 876.29 mi (1,410.25 km) |
| Sikeston to Security-Widefield (Colorado) | 834.61 mi (1,343.18 km) |
| Sikeston to Sedalia (Missouri) | 235.46 mi (378.93 km) |
| Sikeston to Sedro-Woolley (Washington) | 1,823.43 mi (2,934.52 km) |
| Sikeston to Seguin (Texas) | 698.44 mi (1,124.03 km) |
| Sikeston to Selden (New York) | 929.68 mi (1,496.18 km) |
| Sikeston to Selma (Alabama) | 341.15 mi (549.03 km) |
| Sikeston to Selma (California) | 1,656.00 mi (2,665.07 km) |
| Sikeston to Selma (Texas) | 712.50 mi (1,146.66 km) |
| Sikeston to Seminole (Florida) | 739.72 mi (1,190.46 km) |
| Sikeston to Seven Hills (Ohio) | 525.33 mi (845.43 km) |
| Sikeston to Seven Oaks (South Carolina) | 513.80 mi (826.89 km) |
| Sikeston to Severn (Maryland) | 718.17 mi (1,155.78 km) |
| Sikeston to Severna Park (Maryland) | 724.42 mi (1,165.84 km) |
| Sikeston to Sevierville (Tennessee) | 341.81 mi (550.09 km) |
