| Sikeston to Seymour (Indiana) | 246.75 mi (397.10 km) |
| Sikeston to Seymour (Tennessee) | 331.12 mi (532.89 km) |
| Sikeston to Shady Hills (Florida) | 714.45 mi (1,149.80 km) |
| Sikeston to Shafter (California) | 1,647.74 mi (2,651.78 km) |
| Sikeston to Shaker Heights (Ohio) | 534.28 mi (859.84 km) |
| Sikeston to Shakopee (Minnesota) | 581.59 mi (935.98 km) |
| Sikeston to Sharon (Pennsylvania) | 572.24 mi (920.93 km) |
| Sikeston to Sharonville (Ohio) | 326.73 mi (525.83 km) |
| Sikeston to Shasta Lake (California) | 1,774.95 mi (2,856.51 km) |
| Sikeston to Shawnee (Kansas) | 320.16 mi (515.24 km) |
| Sikeston to Shawnee (Oklahoma) | 425.00 mi (683.97 km) |
| Sikeston to Sheboygan (Wisconsin) | 483.58 mi (778.25 km) |
| Sikeston to Shelby (North Carolina) | 462.22 mi (743.88 km) |
| Sikeston to Shelbyville (Indiana) | 276.12 mi (444.37 km) |
| Sikeston to Shelbyville (Kentucky) | 255.59 mi (411.33 km) |
