| Sikeston to Shelbyville (Tennessee) | 199.38 mi (320.87 km) |
| Sikeston to Shelton (Connecticut) | 931.69 mi (1,499.41 km) |
| Sikeston to Shelton (Washington) | 1,844.44 mi (2,968.33 km) |
| Sikeston to Shenandoah (Louisiana) | 455.27 mi (732.69 km) |
| Sikeston to Shepherdsville (Kentucky) | 226.28 mi (364.16 km) |
| Sikeston to Sheridan (Wyoming) | 1,056.77 mi (1,700.71 km) |
| Sikeston to Sherman (Texas) | 456.09 mi (734.01 km) |
| Sikeston to Sherrelwood (Colorado) | 858.43 mi (1,381.50 km) |
| Sikeston to Sherwood (Arkansas) | 202.97 mi (326.65 km) |
| Sikeston to Sherwood (Oregon) | 1,812.14 mi (2,916.36 km) |
| Sikeston to Shiloh (Illinois) | 116.64 mi (187.71 km) |
| Sikeston to Shiloh (Ohio) | 353.76 mi (569.32 km) |
| Sikeston to Shiloh (Pennsylvania) | 723.93 mi (1,165.05 km) |
| Sikeston to Shirley (New York) | 937.40 mi (1,508.60 km) |
| Sikeston to Shively (Kentucky) | 225.73 mi (363.27 km) |
