| Sikeston to Shoreline (Washington) | 1,816.56 mi (2,923.47 km) |
| Sikeston to Shoreview (Minnesota) | 595.78 mi (958.81 km) |
| Sikeston to Shorewood (Illinois) | 328.33 mi (528.39 km) |
| Sikeston to Shorewood (Wisconsin) | 438.11 mi (705.08 km) |
| Sikeston to Short Hills (New Jersey) | 862.28 mi (1,387.71 km) |
| Sikeston to Short Pump (Virginia) | 659.72 mi (1,061.71 km) |
| Sikeston to Show Low (Arizona) | 1,161.10 mi (1,868.61 km) |
| Sikeston to Shreveport (Louisiana) | 387.76 mi (624.04 km) |
| Sikeston to Sicklerville (New Jersey) | 814.45 mi (1,310.73 km) |
| Sikeston to Sidney (Ohio) | 375.40 mi (604.15 km) |
| Sikeston to Sierra Madre (California) | 1,605.47 mi (2,583.76 km) |
| Sikeston to Sierra Vista (Arizona) | 1,237.00 mi (1,990.76 km) |
| Sikeston to Sierra Vista Southeast (Arizona) | 1,234.62 mi (1,986.93 km) |
| Sikeston to Signal Hill (California) | 1,618.66 mi (2,604.99 km) |
| Sikeston to Siloam Springs (Arkansas) | 278.67 mi (448.47 km) |
