| Sikeston to Silver Firs (Washington) | 1,809.42 mi (2,911.98 km) |
| Sikeston to Silver Spring (Maryland) | 699.58 mi (1,125.87 km) |
| Sikeston to Silver Springs Shores (Florida) | 692.99 mi (1,115.26 km) |
| Sikeston to Silverdale (Washington) | 1,830.73 mi (2,946.27 km) |
| Sikeston to Silverton (Oregon) | 1,806.27 mi (2,906.91 km) |
| Sikeston to Simi Valley (California) | 1,642.32 mi (2,643.06 km) |
| Sikeston to Simpsonville (South Carolina) | 436.82 mi (702.99 km) |
| Sikeston to Sioux City (Iowa) | 529.80 mi (852.63 km) |
| Sikeston to Sioux Falls (South Dakota) | 594.02 mi (955.99 km) |
| Sikeston to Skokie (Illinois) | 369.24 mi (594.24 km) |
| Sikeston to Sleepy Hollow (New York) | 891.13 mi (1,434.14 km) |
| Sikeston to Slidell (Louisiana) | 455.93 mi (733.74 km) |
| Sikeston to Smithfield (North Carolina) | 633.34 mi (1,019.27 km) |
| Sikeston to Smithfield (Utah) | 1,232.28 mi (1,983.17 km) |
| Sikeston to Smithville (Missouri) | 321.54 mi (517.47 km) |
