| Sikeston to Smyrna (Delaware) | 777.33 mi (1,251.00 km) |
| Sikeston to Smyrna (Georgia) | 353.77 mi (569.33 km) |
| Sikeston to Smyrna (Tennessee) | 181.58 mi (292.23 km) |
| Sikeston to Snellville (Georgia) | 377.75 mi (607.93 km) |
| Sikeston to Snoqualmie (Washington) | 1,790.40 mi (2,881.37 km) |
| Sikeston to Snyder (Texas) | 703.55 mi (1,132.26 km) |
| Sikeston to Socastee (South Carolina) | 635.81 mi (1,023.24 km) |
| Sikeston to Socorro (Texas) | 1,017.00 mi (1,636.71 km) |
| Sikeston to Soddy-Daisy (Tennessee) | 270.92 mi (436.00 km) |
| Sikeston to Solana Beach (California) | 1,584.36 mi (2,549.78 km) |
| Sikeston to Soledad (California) | 1,752.03 mi (2,819.61 km) |
| Sikeston to Solon (Ohio) | 535.69 mi (862.11 km) |
| Sikeston to Somers Point (New Jersey) | 830.64 mi (1,336.79 km) |
| Sikeston to Somerset (Kentucky) | 274.99 mi (442.55 km) |
| Sikeston to Somerset (New Jersey) | 849.93 mi (1,367.82 km) |
