| Sikeston to Somersworth (New Hampshire) | 1,079.21 mi (1,736.82 km) |
| Sikeston to Somerton (Arizona) | 1,451.66 mi (2,336.22 km) |
| Sikeston to Somerville (Massachusetts) | 1,051.90 mi (1,692.87 km) |
| Sikeston to Somerville (New Jersey) | 845.30 mi (1,360.37 km) |
| Sikeston to Sonoma (California) | 1,792.92 mi (2,885.42 km) |
| Sikeston to Soquel (California) | 1,778.31 mi (2,861.92 km) |
| Sikeston to South Bend (Indiana) | 375.53 mi (604.36 km) |
| Sikeston to South Bradenton (Florida) | 768.74 mi (1,237.17 km) |
| Sikeston to South Burlington (Vermont) | 1,002.06 mi (1,612.66 km) |
| Sikeston to South Charleston (West Virginia) | 442.31 mi (711.83 km) |
| Sikeston to South Daytona (Florida) | 728.48 mi (1,172.37 km) |
| Sikeston to South El Monte (California) | 1,607.51 mi (2,587.03 km) |
| Sikeston to South Elgin (Illinois) | 359.22 mi (578.10 km) |
| Sikeston to South Euclid (Ohio) | 537.27 mi (864.65 km) |
| Sikeston to South Farmingdale (New York) | 906.99 mi (1,459.66 km) |
